INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
Synthesis and preliminar cytotoxic and antifungal evaluation of some 6-N,n-dialkyl 2-aryl-4(3H)-quinazolinone derivatives
Autor/es:
S.LOPEZ; M. ROSALES; C.CANELON; E.A VALVERDE; ROSA NARVAEZ; J.CHARRIS; F.GIANNINI; ENRIZENRIZ] R D; M.CARRASCO; S.ZACCHINO
Revista:
HETEROCYCLIC COMMUNICATIONS
Editorial:
FREUND PUBLISHING HOUSE LTD
Referencias:
Lugar: London; Año: 2001 vol. 5 p. 473 - 473
ISSN:
0793-0283
Resumen:
Some new 2-aryl-4-quinazolinone derivatives bearing a cyciic amino group at position 6 were prepared andtheir prelirninary cytotoxic and antifungal evaluation is reported. They ali showed a moderate cyroroxicity suggestingthar not only che oxidation srate of the N!-C1 bond ís a crucial fac;or fer this kind of biological activity. These,:¡uinazolinones were tested against severa! yeast, füamemous and dermarophyte fungi shc·>nng ali to be inacüve
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