INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
Calculation of tautomer Preferences for Rigid Imidazole Derivatives
Autor/es:
R D ENRIZENRIZ]; E.A.JAUREGUI; F.TOMAS VERT
Revista:
JOURNAL OF MOLECULAR STRUCTURE THEOCHEM
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 1994 vol. 306 p. 115 - 115
ISSN:
0166-1280
Resumen:
The tautomeric preference of rigid imidazole derivatives has been analyzed theoretically from molecular orbitalcalculations ab initio. The present results indicate that the reduced potencies exhibited by imidazolylphenyleneanalogues of cimetidine and metiamide at the H2-receptor are consistent with those hypotheses that defined theN3-H tautomer of the monocation as the only recognizable species in this class of histamine HZ-ligand. However,our results suggest that the ~methylimidazolylphenylene analogue of cimetidine could be an effective histamineH3-antagonist.
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