INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
New Antitumoral Acetogenin “Guanacone type” Derivatives: Isolation and Bioactivity. Molecular Dynamics Simulation of Diacetyl-guanacone
Autor/es:
I.BARRACHINA,I.ROYO,H.A.BALDONI, N. CHARBOUNE, F.SUVIRE, N.DEPEDRO,M.C.ZAFRA-POLO, A.BERMEJO, N.CABEDO, J.SAEZ.,J.TORMO, R.D.ENRIZENRIZ], D.CORTES
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2007 vol. 15 p. 4369 - 4369
ISSN:
0968-0896
Resumen:
Abstract—We describe herein the isolation and semisynthesis of four acetogenin derivatives (1–4) as well as their ability to inhibit the mitochondrial respiratory chain and several tumor cell lines. In addition, four nanoseconds (ns) of MD simulation of compound the mitochondrial respiratory chain and several tumor cell lines. In addition, four nanoseconds (ns) of MD simulation of compound We describe herein the isolation and semisynthesis of four acetogenin derivatives (1–4) as well as their ability to inhibit the mitochondrial respiratory chain and several tumor cell lines. In addition, four nanoseconds (ns) of MD simulation of compound 4, in a fully hydrated POPC bilayer, is reported., in a fully hydrated POPC bilayer, is reported.
rds']