INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
In Vitro Antifungal Evaluation and Structure?Activity Relationships of a New Series of Chalcone Derivatives and Synthetic Analogues, with Inhibitory Properties Against Polymers of the Fungal Cell Wall
Autor/es:
S.LOPEZ; M.CASTELLI; S.ZACCHINO; J.DOMINGUEZ; G.LOBO; J. CHARRIS CHARRIS; J.CORTÉS; J.RIBAS; C,DEVIA; A.M RODRIGUEZ; ENRIZENRIZ] R.D.
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2001 vol. 9 p. 1999 - 1999
ISSN:
0968-0896
Resumen:
Here we report the synthesis, in vitro antifungal evaluation and SAR study of 41 chalcones and analogues. In addition, all active structures were tested for their capacity of inhibiting Saccharomyces cerevisiae b(1,3)-glucan synthase and chitin synthase, enzymes that catalyze the synthesis of the major polymers of the fungal cell wall.
rds']