INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
Correlation of antifungal activity of selected a-substituted acetophenones with their keto?enol tautomerization energy
Autor/es:
A.M RODRIGUEZ; F. GIANNINI,; F.D.SUVIRE; H.A.BALDONI; R. FURLAN; S.ZACCHINO; G.BEKE; P.MATYUS; ENRIZENRIZ] R.D.; I.G. CSIZMADIA
Revista:
JOURNAL OF MOLECULAR STRUCTURE THEOCHEM
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2000 vol. 504 p. 35 - 35
ISSN:
0166-1280
Resumen:
The antifungal activity, measured as minimum inhibitory concentration (MIC) of selected a-substituted acetophenones, showed a linear correlation with the computed enolization energies (DEenolization). This suggested that keto?enol tautomerization plays a significant role in the action mechanism of these a-substituted acetophenones. In order to corroborate this conclusion, two related compounds were synthesized which could not undergo keto?enol tautomerization. Their bioassay proved them to be completely inactive.
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