INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
In Vitro Evaluation of Antifungal Properties of neolignans-8.O.4
Autor/es:
S ZACCHINO; G.RODRIGUEZ; G.PEZENATTI; G.ORELLANA; ENRIZENRIZ] R.D.; M.GONZALEZ SIERRA
Revista:
JOURNAL OF NATURAL PRODUCTS
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 1997 vol. 60 p. 659 - 659
ISSN:
0163-3864
Resumen:
Eighteen racemic 8.O.4¢-neolignans with six different substitution patterns in rings A and B, in their ketone and in their erythro and threo alcoholic forms, were evaluated for antifungal activity by the agar dilution method. Only the alcohols exhibited a broad spectrum of activities against Microsporum canis, Microsporum gypseum, Tricophyton mentagrophytes, Tricophyton rubrum, and Epidermophyton floccosum. (()-erythro-3,4-(methylenedioxy)-7-hydroxy-1¢-allyl- 3¢,5¢-dimethoxy-8.O.4¢-neolignan (11) was the most active compound in the series, and E. floccosum was the most susceptible species.
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