INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
Structure Activity Relationship of Clerodane Diterpenoids Acting as Antifeedant Agents
Autor/es:
ENRIZENRIZ] R.D.; H. BALDONI; E.JAUREGUI; M. SOSA; C.TONN; O. GIORDANO
Revista:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 1994 vol. 42 p. 2958 - 2958
ISSN:
0021-8561
Resumen:
Considering the feeding-deterrent activities exhibited toward Tenebrio molitor (L.) (Coleoptera: Tenebrionidae) of several diterpenes with the clerodane skeleton isolated in our laboratory, a structure-activity relationship study was undertaken. A series of different clerodane diterpenoids was analyzed by performing an exhaustive study of their electronic and conformational behaviors. The results indicate that the antifeedant activity of these clerodane diterpenoids is mediated, at least, through two binding sites. Apparently one important factor contributing to the biological activity is a high conformational flexibility for the torsion angle of the P-fury1 group.
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