ENRIZENRIZ] ricardoricardo] danieldaniel]
Structure-activity relationship study of nitrosopyrimidines acting as antifungal agents
MONICA OLIVELLA; A.MARCHAL; M.NOGUERAS; A.SANCHEZ; M.MELGUIZO; M.RAIMONDI; S.ZACCHINO; F.GIANNINI; J.COBO; ENRIZENRIZ] R.D.
BIOORGANIC & MEDICINAL CHEMISTRY.
PERGAMON-ELSEVIER SCIENCE LTD
Lugar: Amsterdam; Año: 2012
The design, synthesis, in vitro evaluation, and conformational study of nitrosopyrimidine derivatives acting as antifungal agents are reported. Different compounds structurally related with 4,6-bis(alkyl or arylamino)-5-nitrosopyrimidines were evaluated. Some of these nitrosopyrimidines have displayed a significant antifungal activity against human pathogenic strains. In this paper, we report a new group of nitrosopyrimidines acting as antifungal agents. Among them, compounds 2a, 2b and 15, the latter obtained from a molecular modeling study, exhibited antifungal activity against C. albicans, C. tropicalis and C. neoformans. We have performed a conformational and electronic analysis on these compounds by using quantum mechanics calculations in conjunction with Molecular Electrostatic Potentials (MEP) obtained from B3LYP/6-31G(d) calculations. Our experimental and theoretical results have led us to identify a topographical template which may provide a guide for the design of new nitrosopyrimidines with antifungal effects.