INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
Antifungal Activity of Extracts and Prenylated Coumarins Isolated from Baccharis darwinii Hook & Arn. (Asteraceae)
Autor/es:
RITA KURDELAS; BEATRIZ LIMA; ALEJANDRO TAPIA; GABRIELA FERESIN; MANUEL GONZALEZ SIERRA; MARIA VICTORIA RODRIGUEZ; SUSANA ZACCHINO; RICARDORICARDO] DANIELDANIEL] ENRIZENRIZ]; MONICA L. FREILE
Revista:
MOLECULES
Editorial:
MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
Referencias:
Lugar: Basel; Año: 2010 vol. 15 p. 4897 - 4897
ISSN:
1420-3049
Resumen:
The petroleum ether extract of Baccharis darwinii showed activity against Cryptococcus neoformans and dermatophytes. Bioactivity-guided fractionation of Baccharis darwinii has resulted in the isolation of three coumarins: 5’-hydroxy aurapten (anisocoumarin H, 1), aurapten (7-geranyloxycoumarin, 2) and 5’-oxoaurapten (diversinin, 3). The structures of these compounds were characterized by spectroscopic methods. These compounds were evaluated for their antimicrobial activity against a panel of each, bacteria and fungi. Compound 3 showed the best activities against Microsporum gypseum, Trichophyton rubrum and Trichophyton mentagrophytes with MICs = 15.6 μg/mL, followed by compound 1 whose MICs against the same fungi were 62.5 μg/mL. In addition they showed fungicidal rather than fungistatic activity. Both compounds showed moderate activity (MICs = 125 μg/mL) against Cryptococcus neoformans. This is the first report of the presence of compound 1 in B. darwinii.
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