INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
Synthesis and antifungal activity of N-aryl-N-benzylamines and of their homoallyl analogues
Autor/es:
FRANCISCO GARIBOTTO; MAXIMILIANO SORTINO; VALDIMIR KOUZNETSOV; RICARDORICARDO] DANIELDANIEL] ENRIZENRIZ]; SUSANA ZACCHINO
Revista:
ARKIVOC - ONLINE JOURNAL OF ORGANIC CHEMISTRY
Editorial:
ARKAT USA INC
Referencias:
Lugar: Florida; Año: 2011 vol. 7 p. 149 - 149
ISSN:
1551-7004
Resumen:
Ten N-aryl-N-benzylamines were synthesized and evaluated for their antifungal activity, which was compared with their homoallylamine analogues that possessed an allyl group in the carbon next to the nitrogen atom. Results indicated that the absence of the allyl group caused an enhancement of the antifungal activity which could be correlated with the flexibility of the alkyl chain between both aromatic groups. DFT calculations supported these differences in activity.
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