Dysregulation of the inflammatory response in ovary associated to advanced reproductive age.

LARA CASTAGNOLA; ANA SCHAFIR; MARÍA SOLEDAD GORI; LUCILA GALLINO; DAIANA VOTA; AGUSTINA MARCIAL; ANTONIO CATTANEO; MARCELA IRIGOYEN; GUSTAVO MARTÍNEZ; CLAUDIA PÉREZ LEIRÓS; ROSANNA RAMHORST

Congreso; Reunión Anual de La Sociedad Argentina de Inmunología; 2023

The concept of ‘inflammaging’ represents the inflammation associated to aging, which is systemic, chronic and linked to the increase of pro-inflammatory mediators. Even if inflammatory mediators contribute to ovarian physiology, dysregulation of the inflammatory response can affect ovarian reserve and oocyte quality. Our aim is to investigate the mechanisms underlying the exacerbated inflammatory response in ovarian microenvironment associated to advanced reproductive age. Since, oocytes develop in the context of ovarian follicles, we obtained follicular fluid (FF) from women with indication of assisted fertilization treatment and we investigated ovarian immune cell profile associated with clinical parameters. First, we confirmed a negative correlation between the number of oocytes and age. In our population (n=70), we identified two subpopulations: women with >10 oocytes (corresponding to the youngest group, from 21-29y) and