INVESTIGADORES
CERE silvia
artículos
Título:
Functional behavior of chitosan/gelatin/silica - g entamicin coatings by electrophoretic deposition on surgical grade stainless steel
Autor/es:
TUBA AYDEMIR ; LILIANA LIVERAN; JUAN I. PASTORE ; SILVIA CERE; WOLFGANG H. GOLDMANN ; ALDO R. BOCCACCINI; JOSEFINA BALLARRE
Revista:
MATERIALS SCIENCE & ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2020
ISSN:
0928-4931
Resumen:
Metals are used in several orthopedic applications as fixation elements for thestabilization of fractures or as prostheses. One of the most common orthopedic biomaterials in many developing countries is surgical grade stainless steel (SS). However, itsuse as permanent implant in orthopaedic surgery is conditioned due to its limitedcorrosion resistance, osseointegration and absence of antibacterial effect. The aim ofthis work is to generate a degradable coating with antibacterial properties for stainlesssteel to be used in implantable medical devices. The coating is composed of abiopolymer/silica-gentamicin nanoparticles composite obtained by electrophoreticdeposition (EPD) on surgical grade stainless steel plates. The coating surface wascharacterized by microscopic examination and in vitro performance was evaluated afterimmersion in phosphate-buffered saline (PBS) solution, simulated body fluid (SBF) andcell medium, to analyse coating degradation, antibiotics release, cell attachment (ST-2stromal cells) and antibacterial (Escherichia coli and Staphylococcus aureus) properties.EPD coatings were uniform and copy the surface of the SS substrate. Also thedistribution of silica-gentamicin nanoparticles was homogeneous in all of the coatedarea. The degradation of the chitosan-gelatin coatings was evident after 7 days ofimmersion. The gentamicin release showed excellent antibacterial behavior at 24hmeanwhile the cell proliferation at 7 days was not inhibited. The results show that thecoating system presents a promising behavior to prevent hospital infections at early implantation times.