INVESTIGADORES
CERE silvia
artículos
Título:
23. Sol?gel hybrid coatings with strontium-doped 45S5 glass particles for enhancing the performance of stainless steel implants: Electrochemical, bioactive and in vivo response
Autor/es:
SHEILA OMAR; FELIX REPP ; PAULA MARIELA DESIMONE; RICHARD WEINKAMER ; WOLFGANG WAGERMAIER ; SILVIA CERE; JOSEFINA BALLARRE
Revista:
JOURNAL OF NON-CRYSTALLINE SOLIDS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 425 p. 1 - 10
ISSN:
0022-3093
Resumen:
Theprotection of stainless-steel implants by applying a hybrid organic-inorganiccoating generates a barrier for ion migration and a potential holder forfunctional particles. Chemicalcomposition of bioactive silicate-glasses (BG) can be varied to tailor their rate of dissolution in the biologicalenvironment. The substitution of calcium by strontium (Sr) generates alocally-controlled release of Sr-ions to the media. Strontium is known toreduce bone resorption and stimulate bone formation. This work presents coatings made bysol-gel method containing tetraethoxysilane, methyl-triethoxysilane and silicananoparticles as precursors, and functionalized either with BG orSr-substituted BG particles onto surgical grade stainless steel. The coatedimplants were tested in vitro forcorrosion resistance and bioactivity, and invivo to analyze bone formation.The applied coating system providedan excellent protection to aggressive fluids, even after 30 days of immersion. Thepresence of hydroxyapatite is shown as a first evidence of bioactivity. The evaluation of invivo tests in Wistar-Hokkaido rat femur 4 or 8 weeks after the implantationshowed slight differences in thickness of newly formed bone measured by ESEM,and remarkable changes in bone quality characterized with Raman microscopy. Thein vivo response of the coatingscontaining Sr-substituted bioglass is better at early times of implantation as regardsthe bone morphology and quality making this functionalized coatings a verypromising option for implant protection and bone regeneration.