INVESTIGADORES
CERE silvia
artículos
Título:
30. Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model
Autor/es:
MARIA KATUNAR; A. GOMEZ SANCHEZ; JOSEFINA BALLARRE; MATIAS BACA; C. VOTTOLA; JUAN CARLOS ORELLANO; H. SCHELL; G. DUFFO; S. CERÉ
Revista:
Progress in biomaterials
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2014 vol. 3 p. 1 - 10
ISSN:
2194-0509
Resumen:
The mechanical properties and good biocompatibility
of zirconium and some of its alloys make these
materials good candidates for biomedical applications. The
attractive in vivo performance of zirconium is mainly due
to the presence of a protective oxide layer. In this preliminary
study, the surface of pure zirconium modified by
anodisation in acidic media at low potentials to enhance its
barrier protection given by the oxides and osseointegration.
Bare, commercially pure zirconium cylinders were compared
to samples anodised at 30 V through electrochemical
tests and scanning electron microscopy (SEM). For both
conditions, in vivo tests were performed in a rat tibial
osteotomy model. The histological features and fluorochrome-
labelling changes of newly bone formed around
the implants were evaluated on the non-decalcified
sections 63 days after surgery. Electrochemical tests and
SEM images show that the anodisation treatment increases
the barrier effect over the material and the in vivo tests
show continuous newly formed bone around the implant
with a different amount of osteocytes in their lacunae
depending on the region. There was no significant change
in bone thickness around either kind of implant but the
anodised samples had a significantly higher mineral
apposition, suggesting that the anodisation treatment
stimulates and assists the osseointegration process. We
conclude that anodisation treatment at 30 V can stimulate
the implant fixation in a rat model, making zirconium a
strong candidate material for permanent implants.