Preyssler heteropolyacids encapsulated in a silica framework for an efficient preparation of fluorinated hexahydropyrimidine derivatives in solvent-free conditions.

ANGEL G. SATHICQ; DIEGO M. RUIZ; TIERRY CONSTANTIEUX; JEAN RODRIGUEZ; GUSTAVO P. ROMANELLI

SYNLETT

GEORG THIEME VERLAG KG

Año: 2014 p. 881 - 883

0936-5214

A series of trifluoromethylated hexahydropyrimidines was synthesized using a Preyssler heteropolyacid (H14NaP5W29MoO110) encapsulated in a silica framework as catalyst in solvent-free conditions. This synthesis requires short reaction time (1.5 h), 80 ºC temperature in solvent freeconditions to obtain good to excellent yields of 18 hexahydropyrimidine derivatives. Preyssler catalyst embedded in the silica matrix, unlike the bulk or supported on silica, is insoluble in polar media such as acetone, ethanol or methanol, which allows easy removal of the reaction products without affecting their catalytic activity