Oral administration of lipoteichoic acid from Lactobacillus rhamnosus GG overcomes UVB‐induced immunosuppression and impairs skin tumor growth in mice

FRIEDRICH, ADRIÁN D.; CAMPO, VALERIA E.; CELA, ELIANA M.; MORELLI, ADRIAN E.; SHUFESKY, WILLIAM J.; TCKACHEVA, OLGA A.; LEONI, JULIANA; PAZ, MARIELA L.; LARREGINA, ADRIANA T.; GONZÁLEZ MAGLIO, DANIEL H.

EUROPEAN JOURNAL OF IMMUNOLOGY

WILEY-V C H VERLAG GMBH

Año: 2019 vol. 49 p. 2095 - 2102

0014-2980

There is increasing evidence of the relevant connection and regulation between thegut and skin immune axis. In fact, oral administration of lipoteichoic acid (LTA) fromLactobacillus rhamnosus GG (LGG) prevents the development of UV-induced skin tumorsin chronically exposed mice. Here we aim to evaluate whether this LTA is able to revertUV-induced immunosuppression as a mechanism involved in its anti-tumor effect andwhether it has an immunotherapeutic effect against cutaneous squamous cell carcinoma.Using a mouse model of contact hypersensitivity, we demonstrate that LTA overcomesUV-induced skin immunosuppression. This effect was in part achieved by modulating thephenotype of lymph node resident dendritic cells (DC) and the homing of skin migratoryDC. Importantly, oral LTA reduced significantly the growth of established skin tumorsonce UV radiation was discontinued, demonstrating that it has a therapeutic, besidesthe already demonstrated preventive antitumor effect. The data presented here stronglyindicates that oral administration of LTA represents a promising immunotherapeuticapproach for different conditions in which the skin immune system is compromised.