Daily very low UV dose exposure enhances adaptive immunity, compared with a single high-dose exposure. Consequences for the control of a skin infection

CELA, ELIANA M.; GONZALEZ, CINTIA DANIELA; FRIEDRICH, ADRIAN; LEDO, CAMILA; PAZ, MARIELA LAURA; LEONI, JULIANA; GÓMEZ, MARISA INÉS; GONZÁLEZ MAGLIO, DANIEL H.

IMMUNOLOGY

WILEY-BLACKWELL PUBLISHING, INC

Año: 2018

0019-2805

Ultraviolet radiation (UVr) promotes several well-known molecularchanges, which may ultimately impact on health . Some of these effects aredetrimen tal, like inflammation, carcinogenesis and immu nosuppression.On the other hand, UVr also promotes vitamin D synthesis and otherbeneficial effects. We recently demonstrated that exposure to very lowdoses of UVr on four consecutive days [repetitive low UVd (rlUVd)] do esnot promote an inflammatory state, nor the recruitment of neutrophils orlymphocytes, as the exposure to a single high UV dose (shUVd) does.Moreover, rlUVd reinforce the epithelium by increasing antimicrobialpeptides transc ription and epidermal thickness. The aim of this study wasto evaluate the adaptive immune response after shUVd and rlUVd, deter-mining T-cell and B-cell responses. Finally, we challenged animals exposedto both irradiation procedures with Staphylococcus aureus to study theoverall effects of both innate and adaptive immunity during a cutaneousinfection. We observed, as expected, a marked suppression of T-cell andB-cell responses after exposure to an shUVd but a novel and significantincrease in both specific responses after exposure to rlUVd. However, thecontrol of the cutaneous S. aureus infection was defective in this lastgroup, suggesting that responses against pathogens cannot be ruled outfrom isolated stimuli.