INVESTIGADORES
SAAVEDRA Maria Lucila
artículos
Título:
Enhancement of the Enterocin CRL35 Activity by a Synthetic Peptide
Autor/es:
LUCILA SAAVEDRA,1 CARLOS MINAHK,2 A├ŹDA P. DE RUIZ HOLGADO,1 AND FERNANDO SESMA1*
Revista:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Referencias:
Año: 2004 p. 2778 - 2781
ISSN:
0066-4804
Resumen:
The enterocin CRL35 biosynthetic gene cluster was cloned and sequenced. The sequence was revealed to be highly identical to that of the mundticin KS gene cluster (S. Kawamoto, J. Shima, R. Sato, T. Eguchi, S. Ohmomo, J. Shibato, N. Horikoshi, K. Takeshita, and T. Sameshima, Appl. Environ. Microbiol. 68:3830-3840, 2002). Short synthetic peptides were designed based on the bacteriocin sequence and were evaluated in antimicrobial competitive assays. The peptide KYYGNGVSCNKKGCS produced an enhancement of enterocin CRL35 antimicrobial activity in a buffer system