CAMPTOTHECINS AS POTENTIAL CHENOPREVENTIVE AGENTS

MARTINEZ, M.; JUNKINS, P.; PYTON, E.; DE MORENO DE LEBLANC, A; MARIA CAROLINA MALDONADO GALDEANO; WHITACRE, C.

SAN DIEGO- CALIFORNIA

Congreso; Annual Biomedical Research Conference for Minority Students (ABRCMS); 2003

We have recently shown that the CPT analogue Topotecan (TPT), inhibits focal adhesion kinase (FAK) synthesis. Since FAK is involved in angiogenesis, essential to tumor growth, we have hypothesized that TPT may prevent the development of solid tumors by inhibiting angiogenesis. Here we describe our studies on the potential chemopreventive effects of TPT on colon cancer induced by 1,2 dimethylhydrazine (DMH) in a BALB/c mice model  as well as  the angiogenic potencial of TPT using choriollantonic membrane (CAM) assay. The elucidation of the potencial benefits of CPTs as chemopreventive agents may have important implications in the treatment of high-risk and recovering cancer patients.