Immune mechanisms mediated by probiotic bacteria

MALDONADO GALDEANO, CAROLINA; LEMME DUMIT, JOSÉ MARÍA; VELEZ EVA; CAZORLA, SILVIA INES; PERDIGÓN, GABRIELA

Congreso; 10th Anniversary ISIN Madrid 2017; 2016

The gastrointestinal tract is an ecosystems containing microorganisms crucial for the maturation of the immune cells. Probiotic microorganisms induce immune activation through: a) stimulation the epithelial cells(IEC), by adhesion or by their cell wall fragments b) activation of immune cells of the gut c) induce antimicrobial substances d) probiotic interaction with IEC, produce cytokines and chemokines to stimulate the Mucosal Immune System (MIS). We demonstrate: 1) Probiotic bacteria or their fragments interact with the IEC, 2) this activation stimulate the MIS increasing the IgA cells in the intestine, bronchus and breast and inducing inmunomodulation through the cytokine IL10. 3) the IEC induces cytokines as IL6, MCP1 favoring the expansion of LB, the IgA +cells and infiltration of mononuclear cells as macrophages, to produce IL10 and maintain homeostasis.4) The interaction with the IEC, TLRs are involved, and CD206 (mannose receptor) in macrophages and dendritic cells 5) probiotics do not induce inflammatory immune response, only produce a slight increase in the immune cells of the lamina propria 6) The main immune response induced by probiotics is the Innate response; 7) There is not negative effect by the prolonged consumption 8) probiotics in allergy induce Th1 balance with production of IgG not IgE; 9) they induce an increase in the functionality and microbicidal activity in distant cells from the gut as peritoneal and spleen macrophagesProbiotics can modulate the activation/ inflammation, and the immune-regulation of the MIS