INVESTIGADORES
MALDONADO GALDEANO Maria Carolina
congresos y reuniones científicas
Título:
BENEFICIAL EFFECT OF PROBIOTICS CONSUMPTION ON THE IMMUNE SYSTEM
Autor/es:
GABRIELA, PERDIGÓN; CAROLINA, MALDONADO GALDEANO
Lugar:
Buenos Aires
Reunión:
Congreso; IUNS 21st International Congress of Nutrition; 2017
Institución organizadora:
Sociedad Argentina de Nutrición
Resumen:
The gastrointestinal tract is one of the most active microbiologically ecosystems that play a crucial role for the functioning of the Mucosal Immune System (MIS). In this ecosystem, probiotic microorganisms, that enter orally can stimulate the Immune System and induce a network of signals, mediated for the whole bacteria or their cell wall structure (originated by the effect of antimicrobial substances from the Paneth cells): 1) to the intestinal epithelial cells or the immune cells associated, to the lamina propria; 2) the interactions induce the production of different cytokines or chemokine as MCP1 (macrophage chemoattractant) from the IEC, that in turn will send signals to the immune cells, which contribute to the MIS activation. We demonstrate: a) probiotic strains stimulate the mucosal immunity increasing the number of IgA +cells in the intestine, the activity of T cells, and induce inmunomodulation by IL-10 release. We determined the importance of the probiotic viability b) that in the interaction with the epithelial cell and macrophages, Tol like receptors (TLRs), mainly TLR2 are involved, and also the mannose receptor, 3) probiotics favor the innate immune response, where macrophages and DCs play an important role, without inducing an inflammatory immune response, they only produce a slight increase in the cellularity of the lamina propria. We demonstrate the effectiveness of probiotics in Salmonella infection by an increase in the microbicidal activity of peritoneal and spleen macrophages. In malnutrition models with an improvement in the histology of intestine and thymus in both: undernutrition and obesity with an improvements in Immune System functionality. We determine in a respiratory allergy model, that a PFM diminished the levels of IgE by induction of Th1 balance, that favor the production of IgG instead of IgE. These biological mechanisms observed mediated by probiotic stimulation, open the door for the study of anti-inflammatory mechanisms. We demonstrated the anti-inflammatory effect of yogurt in IBD model, where we observed a decrease in the inflammatory cytokine IL-17. We conclude that probiotic strains, PFM and yogurt have an important role in the functionality of the MIS and in the immune surveillance, through the mechanisms of immunoregulation.