“ORAL ADMINISTRATION OF L. casei INCREASES THE IgA CYCLE”

ALEJANDRA DE MORENO DE LEBLANC; CAROLINA MALDONADO GALDEANO; SILVINA CHAVES; GABRIELA PERDIGÓN

BIOCELL

Biocell

Lugar: Mendoza; Año: 2004 vol. 28 p. 54 - 54

0327-9545

Lactic acid bacteria (LAB) used in the fermented products enter to the organism by via oral and interacted with the gut associated lymphoide tissue increasing the cytokine and antibody (principally secretory IgA) production. Cells with information for the antigen can repopulate not only the lamina propria with IgA secreting cells but also they can go to other distant sites such as bronchuses, urogenital tract and mammary glands. Aims: To study the IgA cycle stimulation by oral administration of LAB. Material and Methods: BALB/c mice were fed with L. casei CRL 431 during 2, 5 or 7 days. At the end of the feeding period, the mice were killed and the small intestine, the lung and the breast were removed. IgA+ cells were counted in the tissue slices using indirect immunofluorescence. Results: IgA+ cells increased in the samples taken after 7 days of BAL feeding. In the breast and lung slices, IgA+ cell increased in the fifth day. Conclusion: L. casei showed a local immunostimulated effect in the intestine and through the mucosal common system, also stimulated the immune response in other distant sites. These results permit propose that the oral administration of this BAL can act as oral adjuvant and exerts beneficial effect in different tissues.