INVESTIGADORES
ALVAREZ Gladis Susana
congresos y reuniones científicas
Título:
Respiratory Commensal Bacteria Corynebacterium pseudodiphtheriticum Improves Resistance of Infant Mice to Respiratory Syncytial Virus and Streptococcus pneumoniae Superinfection
Autor/es:
HUMAYUN KOBER AKM; CLUA PATRICIA; TADA ASUKA; VIZOSO PINTO GUADALUPE; KANMANI, PAULRAJ; RODRIGUEZ, CECILIA; HIKARU IIDA; RAYA TONETTI FERNANDA; SALVA SUSANA; ALVAREZ SUSANA; MELNIKOV, VYACHESLAV; KITAZAWA HARUKI; VILLENA JULIO
Lugar:
Valencia
Reunión:
Congreso; 7th Congress of the Federation of European Microbiological Societies (FEMS) and 26th Congress of the Spanish Society for Microbiology (SEM); 2017
Institución organizadora:
FEMS with assocation with SEM
Resumen:
The nasal administration of Corynebacterium pseudodiphtheriticum strain 090104 increases the elimination of Staphylococcus aureus from the nasal cavity in volunteers. The ability of the 090104 strain to improve respiratory immunity or its capacity to increase resistance against respiratory virus were not investigated before. Therefore, this work examined the effect of viable (Cb) or heat-killed (HkCb) C. pseudodiphtheriticum 090104 on the innate respiratory antiviral immune response and the resistance against influenza infection in mice. Adult Balb/c mice were treated with 108 cells of Cb or HkCb by the nasal route during two consecutive days. Treated and untreated control mice were then nasally challenged with influenza virus. Lung tissue damage and respiratory and systemic immune responses were studied at several time points after viral challenge. Cb treatment protected mice by reducing pulmonary injury and lung viral loads. This effect was associated to a differential regulation of the production of antiviral factors since respiratory levels of IFNs were enhanced (p