Non-viable immunobiotic Lactobacillus rhamnosus CRL1505 and its peptidoglycan improve systemic and respiratory innate immune response during recovery of immunocompromised-malnourished mice

YANINA KOLLING; SUSANA SALVA; JULIO VILLENA; GABRIELA MARRANZINO; SUSANA ALVAREZ

Mar del Plata

Congreso; LIX reunión científica anual de la Sociedad Argentina de Investigación Clínica y LXII reunión anual de la Sociedad Argentina de Inmunología; 2014

Sociedad Argentina de Investigación Clínica y Sociedad Argentina de Inmunología

The effect of nasally administered non-viable Lactobacillus rhamnosus CRL1505 (Lr05) and its peptidoglycan (Pg05) on respiratory immunity in malnourished mice was studied. Five experimental groups were used. Weaned mice were malnourished with a protein-free diet (PFD) for 21 days (M group). Aged-matched well-nourished mice consumed a balanced conventional diet (BD) for 21 days and were used as a control group (W group). In addition, malnourished mice received BD during 7d (B group) or BD with nasal non-viable Lr05 (Lr05 group) or its Pg (Pg05 group) supplementation during last 2d of the treatment. On d8, the five groups were infected nasally with Streptococcus pneumoniae (Sp) (106 cells/mouse). Resistance against Sp was significantly reduced in M mice since the levels of lung and blood bacterial cell counts were higher than those detected in W mice (p