INVESTIGADORES
ALVAREZ Gladis Susana
congresos y reuniones científicas
Título:
Alteraciones del sistema de la coagulación durante un proceso inflamatorio inducido en ratones desnutridos. Influencia de Lactobacillus casei
Autor/es:
HARO CECILIA; ALVAREZ SUSANA; VILLENA JULIO; ESPECHE BEATRIZ; AGÜERO GRACIELA
Lugar:
Tafí del Valle. Tucumán
Reunión:
Jornada; XXI Jornadas Científicas de la Asociación de Biología de Tucumán; 2004
Institución organizadora:
Asociación de Biología de Tucumán
Resumen:
This work studied the effect of Lactobacillus casei (Lc) on the coagulation system, during an inflammatory process, in a malnutrition model. Swiss-albino mice were malnourished (M) with protein free diet. Animals were re-nourished for 7d with balanced conventional diet, with (RN+Lc) or without (RN) Lc supplementation (109 UFC/day). Renourished groups, M controls and well-nourished mice (W) were infected intranasally with Streptococcus pneumoniae (103 UFC/mouse) in order to obtain an inflammatory state. During 10d post-infection (dpi) we performed: a)Pletelets counts b)Activated partial thromboplastin time (APTT) c)Prothrombin time (PT) d)Fibrinogen e)Albumin (Ab) concentration and Lactate dehidrogenase activity (LDH) in bronchoalveolar lavages.  Prolonged APTT was observed only in M. PT was markedly altered in M, while RN+Lc showed normal values all period studied. Levels of Ab and LDH were higher in M than in W, but were lower in RN+Lc group than W. Conclusion: re-nutrition supplemented with Lc allowed infected mice to maintain normal PT values, indicating an influence in the extrinsic mechanism of coagulation. Probably it is related with the lower damage observed in lungs.