INVESTIGADORES
ALVAREZ Gladis Susana
artículos
Título:
Are the immunomodulatory properties of Lactobacillus rhamnosus CRL1505 peptidoglycan common for all Lactobacilli during respiratory infection in malnourished mice?
Autor/es:
KOLLING, YANINA; SALVA, SUSANA; VILLENA, JULIO; ALVAREZ, SUSANA
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Año: 2018 vol. 13 p. 1 - 26
ISSN:
1932-6203
Resumen:
Previously, we reported that Lactobacillus rhamnosus CRL1505 peptidoglycan (PG05)improves the innate immune response in immunocompromised-malnourished mice afterStreptococcus pneumoniae infection. This study extends those previous findings by demonstratingthat the dietary recovery of malnourished mice with nasal administration of PG05improves not only the innate immune response but the respiratory and systemic adaptivehumoral response as well. PG05 enhanced the Th2 response, the recovery of B cells, andthe concentration and opsonophagocytic activity of anti-pneumococcal antibodies. In addition,by performing comparative studies with the peptidoglycans from lactobacilli of thesame species (L. rhamnosus CRL534) or with similar immunomodulatory properties (L.plantarum CRL1506), we demonstrated here that PG05 has unique immunomodulatoryproperties that cannot be extended to peptidoglycans from other probiotic strains. However,the knowledge of the molecular characteristics of PG05 is indispensable to understandimmunomodulatory abilities of L. rhamnosus CRL1505.