INVESTIGADORES
ALVAREZ Gladis Susana
artículos
Título:
Recent Advances and Future Perspective in Microbiota and Probiotics
Autor/es:
HARUKI KITAZAWA; SUSANA ALVAREZ; ALEXANDER SUVOROV; VYACHESLAV MELNIKOV; JULIO VILLENA; BORJA SANCHEZ
Revista:
Biomed Research International
Editorial:
Hindawi
Referencias:
Año: 2015
ISSN:
2314-6133
Resumen:
Recent studies have highlighted the critical role of intestinal microbes on gut health. The various bacterial communities in the gut have many functions including metabolic, barrier effect, and trophic and immunological functions. Hence it has been demonstrated that alterations in gut microbiota could have negative consequences in health. In addition, there is a growing body of evidence to support the potential use of probiotics in the prevention and treatment of various human and animal diseases. Numerous probiotic studies such as different lactic acid bacteria (LAB) strains have been performed in humans and animal models to investigate their beneficial effects. Overall there is encouraging evidence that specific probiotic strains are valuable in the prevention and treatment of different diseases and their successful application is related to the better understanding of the mechanisms of probiotic action. A great progress in understanding cellular and molecular interactions between microbiota and probiotics with host cells has been achieved in the past years. It has been also discovered that commensal microorganisms and probiotics can influence the host health by products like metabolites, cell wall components and DNA/RNA. Therefore, beneficial effects might be even achieved with dead probiotic bacteria or just probiotics-derived components like peptidoglycan fragments, secreted peptides or DNA/RNA. The identification and characterization of the probiotic molecules as ligands for specific host receptors was key in understanding probiotic function. In this special issue, authors will focus on microbiota, their effect on gut health and the consequences of their alterations. In addition, expert international authors will describe the most recent cutting-edge research in the use of probiotics and their bioactive compounds to prevent and improve different health disorders. We are interested in articles that explore aspects of microbiota and probiotic actions in humans and also in animals. We invite authors to submit original research and review articles that seek to advance in the understanding of commensal microorganisms or probiotics actions as well as novel applications of probiotics.