Optimization of a chromatographic method for the simultaneous determination of amoxicillin and sulbactam pivoxil in pharmaceutical formulations

RAZUC, M.; CABRERA F.; RAMÍREZ RIGO M.V.

Rosario

Congreso; 4ta. Reunión Internacional de Ciencias Farmacéuticas; 2016

RICIFA

The combination of Amoxicillin-AMOX and Sulbactam pivoxil-SULB is administrated as tablets and oral suspensions in the treatment of bacterial infections. The quality control of these formulations included, among others, uniformity of content and dissolution test. There is not pharmacopoeial methods to determine Sulbactam pivoxil alone or combined. Although Qi et al.(2003) proposed the simultaneous determination of both drugs using HPLC and UV-determination, the area ratio is very high (>8) what make it difficult to use it mainly in the dissolution test. The purpose of this work is to optimize the operative conditions of a HPLC method for the simultaneous determination of AMOX and SULB, in term of area ratio and retention time.