PERSONAL DE APOYO
CABRERA fernanda Anabel
congresos y reuniones científicas
Título:
Solid state characterization and cytotoxicity evaluation of inhalatory microparticles based on indomethacin-polylysine complex
Autor/es:
CESCHAN N.; BUCALÁ V.; RAMÍREZ RIGO M.V.; SMYTH H.; CABRERA F.
Lugar:
Río de Janeiro
Reunión:
Congreso; XVIII Congresso da Federación Farmacéutica Sudamericana 8º Congresso RIOPHARMA de Ciências Farmacêuticas; 2015
Institución organizadora:
FEFAS
Resumen:
Aclaración: En esta publicación participe como colaboradora, asistiendo en el uso de equipos y puesta a punto de técnicas de caracterización. Estoy incluida en los agradecimientos.Indomethacin (IN) is a non-steroidal anti-inflammatory drug that reduces pain and inflammation in rheumatoid arthritis. When administered by the oral route, IN exhibits variable bioavailability and produces undesirable gastrointestinal side effects. To overcome these problems, IN has been proposed for pulmonary administration (1). In the design of new inhalable materials, lung accessibility and absence of toxicity are important challenges. Microparticles based on IN and polylysine (PL, a cationic polymer) were previously obtained by spray drying (SD)(2). The SD process parameters were selected in order to obtain particles with aerosolization-deposition properties suitable for IN inhalatory delivery(2). The aim of the work is to characterize the solid state of the particulate material and to study the cytotoxic effect on a model lung cell line