INVESTIGADORES
GIACOMODONATO Monica Nancy
artículos
Título:
Salmonella enterica Serovar Enteritidis Enterocolitis during Late Stages of Gestation Induces an Adverse Pregnancy Outcome in the Murine Model.
Autor/es:
NOTO LLANA M,; SARNACKI SH,; AYA CASTAñEDA MR,; PUSTOVRH MC, ; GARTNER AS,; BUZZOLA FR, ; CERQUETTI MC, ; GIACOMODONATO MN,
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Lugar: San Francisco; Año: 2014 vol. 9 p. 111282 - 111282
ISSN:
1932-6203
Resumen:
Foodborne diseases caused by Salmonella enterica serovar Enteritidis (S. Enteritidis) are a significant health problem.Pregnancy, state of immunological tolerance, is a predisposing condition for the development of infections withintracellular pathogens. Salmonella species can cause pregnancy complications such as chorioamnionitis, transplacentalfetal infection, pre term labor, abortions, neonatal and maternal septicemia. However, the specific mechanisms by whichSalmonella infections trigger these alterations are not clear. In the present work, using a self-limiting enterocolitis murinemodel, we show that the ingestion of a low dose of S. Enteritidis at late stages of pregnancy (day 15 of gestation) issufficient to induce massive maternal infection. We found that Salmonella infection leads to 40% of pre term delivery, 33%of abortion and fetal growth restriction. Placental dysfunction during S. Enteritidis enterocolitis was confirmed throughcellular infiltration and hypoxia markers (MPO activity and COX-1 and COX-2 expression, respectively). Apoptosis inplacental tissue due to Salmonella infection was also evident at day 18 of gestation when investigated by morphometricprocedure, DNA fragmentation and Fas/FasL expression. Also, the expression of IFN-c, TNF-a, IL-17 and IL-10 was upregulated in response to Salmonella not only in placenta, but also in amniotic fluid and maternal serum. Altogether, ourresults demonstrate that S. Enteritidis enterocolitis during late stages of gestation causes detrimental effect on pregnancyoutcome.