Dam and its role in pathogenicity of Salmonella enterica.

GIACOMODONATO MN, SARNACKI SH, NOTO LLANA M, , CERQUETTI MC

Journal of infection in developing Countries

Open Learning on Enteric Pathogens

Año: 2009 vol. 3 p. 484 - 490

2036-6590

Dam methylation is an essential factor involved in the virulence of an increasing number of bacterial pathogens including Salmonella enterica. Lack of Dam methylation causes severe attenuation in animal models. It has been proposed that dysregulation of Dam activity is potentially a general strategy for the generation of vaccines against bacterial pathogens. In this review, we focus our attention on the role of methylation by Dam protein in regulating bacterial gene expression and virulence in Salmonella enterica.