Effects of bariatric surgery on hepatic and intestinal lipoprotein particle metabolism in obese, nondiabetic humans.

PADILLA, NADEGE ; MARANINCHI, M; BELIARD, S; BERTHET, B; NOGUEIRA, JP; WOLFF, E; NICOLAY, A; BÉGU, A; DUBOIS, N; GRANGEOT R; MATTEI C; VIALETTES B; XIAO C; LEWIS, GF; VALERO, R

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LIPPINCOTT WILLIAMS & WILKINS

Lugar: Philadelphia; Año: 2014

1079-5642

Objective?The dyslipidemia of obesity and other insulin-resistant states is characterized by the elevation of plasma triglyceride-rich lipoproteins (TRL) of both hepatic (apoB-100?containing very low-density lipoprotein) and intestinal (apoB-48?containing chylomicrons) origin. Bariatric surgery is a well-established and effective modality for the treatment of obesity and is associated with improvements in several metabolic abnormalities associated with obesity, including a reduction in plasma triglycerides. Here, we have investigated the effect of bariatric surgery on TRL metabolism.Approach and Results?Twenty-two nondiabetic, obese subjects undergoing bariatric surgery: sleeve gastrectomy (n=12) or gastric bypass (n=10) were studied. Each subject underwent 1 lipoprotein turnover study 1 month before surgery followed by a second study, 6 months after surgery, using established stable isotope enrichment methodology, in constant fed state. TRL-apoB-100 concentration was significantly reduced after sleeve gastrectomy, explained by a decrease (P