Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa

NOGUEIRA JP, MARANINCHI M, LOREC AM, CORROLLER AB, NICOLAY A, GAUDART J, PORTUGAL H, BARONE R, VIALETTES B, VALÉRO R.

EUROPEAN JOURNAL OF CLINICAL NUTRITION

NATURE PUBLISHING GROUP

Año: 2010 vol. 19 p. 1 - 5

0954-3007

Objective: The aim of our study was to determine whether eating behaviors and/or physical activity level may explain contradicting results in adipocytokines levels in anorexia nervosa (AN). Subjects/Methods: Fasting levels of circulating adipocytokines (adiponectin, resistin and leptin), insulin, glucose, C-reactive protein, cytokines (tumor necrosis factor-a and interleukin (IL)-1b), body composition and resting energy expenditure were measured in 24 women AN patients and 14 women controls. These parameters were compared according to AN subtypes: 15 patients with restrictive (R-AN) form versus 9 patients with binge/purge (BP-AN) form; 15 patients with hyperactive (H-AN) form versus 9 patients with nonhyperactive (NH-AN) form. Results: BP-AN patients had significantly higher serum adiponectin levels compared with R-AN patients (P<0.05), and H-ANpatients had higher serum leptin and lower serum resistin levels compared with NH-AN patients (P<0.05 for both). Conclusions: Our study shows specific adipocytokines profiles depending on the subtype of AN: restrictive versus binge/purge and hyperactive versus Nonhyperactive forms. We suggest that these biological signatures could interfere with the outcome of the disease.