Cytokine-induced endoplasmic reticulum stress in -cells is ameliorated by compound A.

ANDREONE, L; GIMENO, ML; FUERTES, F; BARCALA TABARROZZI, AE; ARIOLFO, L; LIBERMAN, AC; GERLO, S; DE BOSSCHER, K; PERONE, MJ

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that selectively destroys insulin producing β-cells. ER stress and subsequent insulin secretory deficiency in β-cells precede the onset of autoimmune diabetes. Pro-inflammatory cytokines (IL-1+IFN-; CYT) signaling leads to activation of ER stress in β-cells. We reported that Compound A (2-(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride; CpdA), a dissociative glucocorticoid receptor (GR)-ligand, is an effective modulator of T and dendritic cells. The aim of this study was to explore the beneficial effects of CpdA on CYT-induced β-cell ER stress; the classic GR-ligand dexamethasone was used for comparison. CpdA significantly reduced CYT-induced NO secretion by the insulinoma INS-1E cells (p