INVESTIGADORES
PERONE Marcelo Javier
artículos
Título:
Disease-modifying immunotherapy for the management of autoimmune diabetes
Autor/es:
CASTRO, CN; BARCALA TABARROZI, AE; ANTUNICA NOGUEROL, M; LIBERMAN, AC; DEWEY, RA; ARZT, E; MORELLI, AE; PERONE, MJ
Revista:
NEUROIMMUNOMODULATION.
Editorial:
KARGER
Referencias:
Año: 2010 vol. 17 p. 173 - 173
ISSN:
1021-7401
Resumen:
Type 1 diabetes (T1D) is a T cell-mediated autoimmune diseasethat destroys the insulin-secreting  -cells of the pancreas.It is now possible to predict those candidates that willprogress to T1D before the full onset of the disease. Preventionof uncontrollable autoimmunity against  -cells in therapiesfor T1D is mandatory to preserve the  -cell mass.Therefore, immunomodulatory strategies directed to inhibitingthe activity of self-reactive T cell clones as well as inductionof regulatory T cells would be beneficial for preventionof T1D or recurrence of  -cell autoimmunity against islet cellallografts.
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