Androgens and androgen receptor action in skin and hair follicles

CERUTI, JULIETA MARÍA; LEIROS, GUSTAVO JOSÉ; BALAÑÁ , MARÍA EUGENIA

MOLECULAR AND CELLULAR ENDOCRINOLOGY.

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2018 p. 122 - 133

0303-7207

Beyond sexual functions, androgens exert their action in skinphysiology and pathophysiology. Skin cells are able to synthesize most ofactive androgens from gonadal or adrenal precursors and the enzymesinvolved in skin steroidogenesis are implicated both in normal orpathological processes. Even when the role of androgens and androgenreceptor (AR) in skin pathologies has been studied for decades, theirmolecular mechanisms in skin disorders remain largely unknown. Here, wego over recent studies of androgens and AR roles in several skin-relateddisorders, focusing in the current understanding of its molecularmechanisms in androgenetic alopecia (AGA). We review on the molecularpathophysiology of type 2 5α-reductase, AR coactivators, the paracrinefactors deregulated in dermal papilla (such as TGF-β, IGF 1, WNTs andDKK-1 ) and the crosstalk between AR and Wnt signalling in order to shedsome light on new promising treatments.