? Oligonucleotide therapy for skin and hair: A new pharmacological paradigm.

KERNER, N.; BALAÑA, ME; ALVAREZ ROGER MC; DUGOUR AV

Kosmetische Medizin

Grosse Verlag

Lugar: Berlin; Año: 2006 vol. 27 p. 216 - 219

1430-4031

Oligonucleotides constitute a new class of therapeutics which is very attractive as they act at the level of gene expression. The simplicity of their concept, rational design and knowledge of the human genome sequence has led to a huge approval of this new pharmacological paradigm. Their growing vast usages have pushed the development of optimized chemical synthesis methods of oligonucleotides introducing odifications, automation and improving yields, turnaround time, costs and suitability. Cutaneous oligonucleotides delivery provides the best administration route as a result of the proximity of the affected organ. That is why oligonucleotide therapy seems to be predestinated to become the first choice in skin and hair disorder treatments. However, the application of oligonucleotides as drugs presents significant challenges in the capability of cell penetration as well as half-life, non-specific binding and pharmacokinetics. The main therapeutic strategies for treatment of androgen-related dermatological disorders used until now are not completely satisfactory in terms of clinical efficacy and potential secondary effects. Thus, there is a need of a new generation of antiandrogens for better therapeutic results. That is the reason for making a great effort focusing on igonucleotide and antisense strategies.