BECAS
CEBRÓN Julieta RocÍo
congresos y reuniones científicas
Título:
Oncogenic potential of prolonged growth hormone (GH)-administration in adult mice liver
Autor/es:
CICCONI NADIA; CEBRÓN JULIETA; MIQUET JOHANNA; SOTELO ANA
Lugar:
Mar del Plata
Reunión:
Congreso; LXIV Reunión anual de la Sociedad Argentina de Investigaciones Clínicas (SAIC).; 2019
Institución organizadora:
SAIC
Resumen:
Growth hormone (GH) is given to childrenwith growth impairment and to adults under catabolic states,even if they are not GH-deficient. Chronic exposure to elevatedGH levels induces pro-oncogenic liver pathology; GH-overexpressing transgenic mice develop liver tumors at advancedages. We had evaluated the effect of 5-week GH-treatment,given with the hepatic tumor inductor diethylnitrosamine (DEN),on tumor formation in growing male mice liver. GH did notpromote tumor formation, nor did GH given with DEN increasethe number of hepatic lesions in growing mice. The aim of thisstudy was to assess if the same prolonged GH pharmacologicaltreatment would induce any alterations when given to 5 month-old mice. Livers (n= 7-9) were collected at 48 weeks of age andvisually inspected. GH-treatment alone did not induce visiblelesions. DEN treatment induced liver tumor formation, whereascombination with GH did not promote further tumordevelopment. Microscopical evaluation revealed that only DEN-treated groups exhibited dysplastic foci, although non-significantdifferences were attained with GH-treatment. The number ofhepatocytes per microscopic field was increased in the dysplasticfoci compared to the surrounding tissue (p