Induction of the tolerogenic dendritic cells DC-10 into the decidua: the contribution of trophoblast cells

SCHAFIR A; HAUK V; LARA B; FERNÁNDEZ L; BLEJER J; GRASSI BASSINO A; PÉREZ LEIRÓS C; RAMHORST R; GORI S

Mar del Plata

Congreso; Reunión Científica Anual de la Sociedad Argentina de Inmunología; 2023

Sociedad Argentina de Inmunología (SAI)

Immunomodulation and tolerance induction are strictly required during pregnancy. A novel and distinctive subset of HLA-G+ tolerogenic dendritic cell, DC-10, was found increased in first-trimester decidua. Recently, we showed that decidualized cells can condition maternal monocytes to DC-10 profile during the pre-implantation period. Here we aimed to explore the potential contribution of DC-10 in first-trimester decidua and the impact of trophoblast cells in its induction. First, we performed an integrated bioinformatic analysis since public array-based data. We found 212 up-regulated genes in DC-10 relative to mature and immature DC (p