SERUM PERIOSTIN LEVELS IN FIBROUS DYSPLASIA: ITS USEFULNESS AS DISEASE BIOMARKER - AN EXPLORATORY STUDY

MASTAGLIA, SILVINA; GONZÁLEZ, DIANA; TETZLAFF, TW; BONANNO MARINA SOLEDAD; GIANOTTI, GR; FERNÁNDEZ, FC; GÓMEZ GLORIOSO, GGD; OLIVERI, BEATRIZ

Barcelona

Congreso; WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES; 2020

WCO-IOF-ESCEO

Objective: Fibrous dysplasia (FD) is a rare, non-hereditary bone disease caused by a somatic mutation of GNAS gene. Periostin (Postn) is a new marker, linked to bone repair processes. We aimed to assess Postn sensitivity as disease activity marker of FD.Methods: An exploratory case-control study was led, with 15 FD patients, paired by age and gender with healthy subjects (controls). Postn serum levels were gauged in FD patients and controls, also according to clinical manifestation. In the same assay, with serum samples stored at -80°C, Postn was measured by the ELISA method (Sigma Aldrich; St. Louis, USA), [coefficient of variation (%CV) intra-assay