Aminobisphosphonate‐treated ewes as a model of osteonecrosis of the jaw and of dental implant failure

DAVISON, MARIO R.; LYARDET, LEONARDO; PRELIASCO, MARIANA; YAFUL, GRACIELA; TORRES, PERLA; BONANNO, MARINA S.; PELLEGRINI, GRETEL G.; ZENI, SUSANA N.

JOURNAL OF PERIODONTOLOGY

AMER ACAD PERIODONTOLOGY

Año: 2019

0022-3492

AbstractBackground:Bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) anddental implant failure are two negative side effects of chronic aminoBP treatment.Methods:Eleven ovariectomized (OVX) ewes and four ewes subjected to shamsurgery (SHAM) were treated as follows: OVX (n=5): OVX plus saline solution;zoledronic acid-treated group (ZOL) (n=6): OVX plus ZOL; SHAM (n=4): SHAMplus saline solution. Extraction of the first upper molar was performed at 1 year, dentalimplant placement at 2 years, and sacrifice at 28 months.Results:Implants remained in place in SHAM and OVX ewes but were lost in all ZOLewes. ZOL sheep (2/6) showed inflammation and necrotic bone at mandibular region.No differences in serum calcium (Ca), inorganic phosphate (Pi) or 25-hydroxyvitaminD were observed, whereas bone alkaline phosphatase levels decreased in the threestudied groups (P