Visuomotor adaptation promotes spindle clustering and fast spindle-SO coupling locally, over the contralateral motor network

AGUSTIN SOLANO; LUIS A RIQUELME; DANIEL PEREZ CHADA; VALERIA DELLA MAGGIORE

Congreso; Neuroscience 2021 - SfN Annual Meeting; 2021

Society for Neuroscience

The last decade has seen remarkable progress in the identification of the neural signatures of sleep-dependent consolidation. Yet, most advances have emerged from the field of declarative memory, possibly due to the substantial evidence suggesting that only hippocampal dependent learning benefit from sleep. Overnight reactivation of hippocampal memories appears to depend on the precise synchrony between slow oscillations (SO) and sleep spindles (Muehlroth et al., 2019). Here, we sought to examine whether this coupling is also critical for the consolidation of human motor memories. With the objective of identifying the neural signatures supporting sleep stabilization of visuomotor adaptation (VMA) memories in humans, a set of subjects (n = 10) was exposed to a VMA session and a control (CTL) session without visual perturbation. Subjects went to bed 10 min after each training session, and EEG recordings were obtained throughout a whole night of sleep. We found that VMA increased the overall density of fast (≥12 Hz) but not slow (