ARIZA BAREÑO Lizeth Aixa
congresos y reuniones científicas
Norcantharidin and Levoglucosenone: new natural alternatives for breast cancer treatment.
ARIZA BAREÑO, LIZETH AIXA; DELBART, DAMIAN IGNACIO; BECHIS, ANDRÉS; AMIGO, NATALIA; TARUSELLI, MARÍA AGUSTINA; TODARO, LAURA BEATRIZ; URTREGER, ALEJANDRO JORGE
Ciudad Autónoma de Buenos Aires
Simposio; BUENOS AIRES BREAST CANCER SYMPOSIUM BA-BCS 2021; 2021
Breast cancer is a major public health problem, being the second leading cause of cancer death among women in developed countries. Given the need for new therapeutic alternatives, in this work we have studied the antitumor activity of two different natural compounds in order to evaluate their potential use in clinical settings.Norcantharidin (NCTD) is a demethylated form of cantharidin,an active componentpresent in Mylabris beetles and levoglucosenone (Levo) is obtained after the pyrolytic treatment of soybean hulls. NCTD showed an IC50 of 35 and 56 μM in 4T1 (murine) and Hs578T (human) mammary cell lines respectively. Levo and structurally related derivatives (compounds 2, 3 and 4) were analyzed in LM3 (murine) and MDA-MB 231 (human) cell lines showing an IC50 of12 and 50 μMrespectively.In both natural compounds, anti-proliferative effects were associated with apoptosisinduction.Nevertheless, NCTD also induced a time-sustained reduction in ERK activated levels (p-ERK).Moreover, in vitro, both compounds significantly reduced the adhesive and migratory capacities as well as secreted MMP-9 activity in a dose-dependent manner(p