Long-term analysis of antibodies elicited by SPUTNIK V: A prospective cohort study in Tucumán, Argentina

CHAHLA, ROSSANA ELENA; TOMAS-GRAU, RODRIGO HERNÁN; CAZORLA, SILVIA INÉS; PLOPER, DIEGO; VERA PINGITORE, ESTEBAN; LÓPEZ, MÓNICA AGUILAR; AZNAR, PATRICIA; ALCORTA, MARÍA ELENA; VÉLEZ, EVA MARÍA DEL MAR; STAGNETTO, AGUSTÍN; ÁVILA, CÉSAR LUÍS; MALDONADO-GALDEANO, CAROLINA; SOCIAS, SERGIO BENJAMÍN; HEINZE, DAR; NAVARRO, SILVIA ADRIANA; LLAPUR, CONRADO JUAN; COSTA, DARDO; FLORES, ISOLINA; EDELSTEIN, ALEXIS; KOWDLE, SHREYAS; PERANDONES, CLAUDIA; LEE, BENHUR; APFELBAUM, GABRIELA; MOSTOSLAVSKY, RAÚL; MOSTOSLAVSKY, GUSTAVO; PERDIGÓN, GABRIELA; CHEHÍN, ROSANA NIEVES

The Lancet Regional Health - Americas

Elsevier

Año: 2022 vol. 6

2667-193X

BackgroundGam-COVID-Vac (SPUTNIK V) has been granted emergency use authorization in 70 nations and has been administered to millions worldwide. However, there are very few peer-reviewed studies describing its effects. Independent reports regarding safety and effectiveness could accelerate the final approval by the WHO. We aimed to study the long-term humoral immune response in naïve and previously infected volunteers who received SPUTNIK V.MethodsHumoral immune responses, assayed by anti-SARS-CoV-2-spike-RBD IgG ELISA and neutralization assays, were measured in 602 healthcare workers at 0, 14, 28, 60 and 180 days after receiving SPUTNIK V between December 2020 and July 2021 in Tucumán, Argentina.FindingsSeroconversion was detected in 97% of individuals after 28 days post-vaccination (dpv) (N = 405). Anti-RBD titers began to decrease after 60 dpv (N = 328), but remained detectable in 94% at 90 dpv (N = 224). At 180 dpv, anti-RDB titers persisted in 31% (N = 146). Previous infection triggered an increased immune response to the first dose and increased neutralization activity against variants of concern (VOC). Second doses in previously infected individuals further increased titers, even 90 dpv (N = 75). Basal antibody titers had more influence on post-vaccination anti-RBD responses than the time elapsed between diagnosis and vaccination (N = 274).InterpretationData presented herein provides essential knowledge regarding the kinetics of antibodies induced by SPUTNIK V up to six months after immunization, and suggests that when considering one-dose vaccination policies for individuals with previous SARS-CoV-2 infection, serological studies to determine basal titers may be important, independent of when diagnosis occurred.FundingTucumán Public Health System (SIPROSA), Argentinean National Research Council (CONICET), National University of Tucumán (UNT).