PERSONAL DE APOYO
FASCIO Mirta Liliana
artículos
Título:
New acridinone derivative with trypanocidal activity
Autor/es:
GILBERTO L. PARDO ANDREU; NATALIA M. INADA; ROLANDO F. PELLÓN; MAITE L. DOCAMPO; MIRTA L. FASCIO; NORMA B. D´ACCORSO; ANÍBAL E. VERCESI
Revista:
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Editorial:
Elsevier
Referencias:
Año: 2008 vol. 31 p. 502 - 504
ISSN:
0924-8579
Resumen:
Diseases caused by protozoal parasites remain an important human health problem, despite much progress in understanding the biology of these organisms. Present chemotherapies are inadequate, toxic or are becoming ineffective due to an increase in resistance. Chagas disease, caused by Trypanosoma cruzi, is endemic in Latin America and affects around 15 million people In the present study, we obtained for the first time 10-allyl-6-chloro-2-fluoro-9(10H)-acridinone (AD-1) and evaluated its in vitro trypanocidal activity.
