INVESTIGADORES
LUJAN Adela Maria
congresos y reuniones científicas
Título:
Adaptation in Pseudomonas aeruginosa biofilms driven by mismatch repair system-deficient mutators
Autor/es:
LUJAN, ADELA M; MACIÁ, MARÍA DOLORES; YANG, LIANG; MOLIN, SOEREN; OLIVER, ANTONIO; SMANIA, ANDREA M
Lugar:
COPENAGUE
Reunión:
Conferencia; EUROBIOFILMS 2011; 2011
Institución organizadora:
European Society of Clinical Microbiology and Infectious Diseases
Resumen:
The aim of the present study was to investigate the structure, phenotypic diversification and competitiveness of Pseudomonas aeruginosa hypermutator biofilms. For this purpose, the environmental strain Hex1T and its respective mutS mutant, Hex1TMS, were grown in flow-cell biofilms and inspected by confocal laser scanning microscopy. Structural analyses revealed that biofilms formed by Hex1TMS strain were similar to those formed by Hex1T strain, displaying the characteristic mushroom-shaped structures of P. aeruginosa biofilms. However, hypermutator biofilms showed significantly increased phenotypic diversity in comparison to wild type biofilms, with a Shannon-Weaver Index (H) of 0.31 and 0.03, respectively (P