Fluorescent and Magnetic Stellate Mesoporous Silica for Bimodal Bioimaging

FRANCIS PERTON; MARIANA TASSO; MATHILDE MÉNARD; CRISTINA BLANCO ANDUJAR; SÉBASTIEN HARLEPP; DOMINIQUE BÉGIN; DAMIEN MERTZ; SYLVIE BEGIN-COLIN

Bastia

Conferencia; Nanohybride XIV; 2017

The design and development of bimodal sensors combining the high resolution of MRI imaging and the sensitivity of fluorescence microscopy for nanomedicine has known a tremendous interest this last decade. However, the combination of these properties requires a high control over the synthesis with a potential high yield. In this work, iron oxide silica core-shell nanoparticles were synthesized, in which small carboxylated commercial CdSe/ZnS quantum dots were grafted to confer fluorescence properties. In an attempt to control the interactions of the NPs with cancerous cells, a polymeric shell made of human serum albumine (HSA) was coated at the surface of the nanocomposites.