MACHICOTE AndrÉs Pablo
The early onset of type 1 autoimmune hepatitis has a strong genetic influence: role of HLA and KIR genes
PODHORZER, A.; PALADINO, N.; CUARTEROLO, M.L.; FAINBOIM, H.A.; PAZ, S.; THEILER, G.; CAPUCCHIO, M.; LÓPEZ, S.I.; MACHICOTE, A.; MONTAL, S.; PODESTA, G.; FAINBOIM, L.
GENES AND IMMUNITY
NATURE PUBLISHING GROUP
Año: 2016 vol. 17 p. 187 - 187
We have previously reported a strong association between HLA-DRB1∗1301 and type 1 pediatric autoimmune hepatitis (PAH) and between HLA-DR∗0405 and adult autoimmune hepatitis (AAH). Because human killer cell immunoglobulin-like receptors are known to be associated with susceptibility to autoimmune diseases, we investigated the frequencies of HLA-A, B, C, DRB1 and KIR genes in 144 type 1 PAH and 86 AAH patients, which were compared with 273 healthy controls. We demonstrated in PAH the increased frequency of the functional form of KIR2DS4-Full Length (KIR2DS4-FL), which in combination with HLA-DRB1∗1301 revealed a strong synergistic effect (odds ratio=36.5). PAH-KIR2DS4-FL+ subjects have shown an increased frequency of their putative HLA-C∗02, 04 and 06 ligands. KIR analysis of PAH also revealed a decreased frequency of KIR2DL2 gene and its ligand. In contrast, AAH cases have shown a weaker increased frequency of KIR2DS4-FL, a lack of synergistic effect with HLA class II antigens and a moderate association with HLA-DRB1∗0405. Of note, we demonstrated that liver T cells have a unique pattern of KIR expression. These results show a KIR gene involved in autoimmune hepatitis and suggest a stronger genetic influence for the early onset type I autoimmune hepatitis.