PERSONAL DE APOYO
LEWICKI Marianela
congresos y reuniones científicas
Título:
Puesta a punto de un modelo experimental de distracción osteogénica mandibular en ratas Wistar.
Autor/es:
PUJADAS BIGI M; LEWICKI M; SIVAK M; MANDALUNIS PM; UBIOS AM
Lugar:
Mar del Plata, Buenos Aires
Reunión:
Congreso; XL Reunión Anual de la Sociedad Argentina de Investigación Odontológica; 2007
Institución organizadora:
SAIO
Resumen:
Introduction: Distraction osteogenesis is a surgical technique that permits new bone formation trough the gradual ends separation from an osteotomized bone. The purpose of this work was to evaluate bone regeneration after removing mandibular molars in Wistar rats with the objective to use healed bone without molars to design an experimental model of distraction osteogenesis. Materials and methods: Male Wistar rats weighing 120 g were used and mandibular molars extraction was performed. A distractor made with an steel stainless expansion screw MINI Dentaurum®  with two ends made of acrylic, where we fixed two micro implants MITO de B&W® (1,4 mm in width and 7 mm in length was fabricated. At 4 months of age, when animals ranged 350 g of body weight, under general anesthesia, right mandibular surgery (osteotomy) was performed and the distractor was installed. Left mandibule was used as control. This preliminary study of an experimental model of distraction osteogenesis in rat is original because distraction osteogenesis was performed on bone mandibular healed originated from ectomesenchymal cells. Results: The amount of bone obtained after molar extraction is enough to study bone regeneration after distraction osteogenesis. Conclusion: The present study shows that our experimental model will allow study distraction osteogenesis on bone originated from intramembranous ossification, and it could be used to evaluate distraction osteogenesis in several experimental conditions that affect  bone modeling and remodeling.Key words:  distraction osteogenesis, bone healing, bone distractor, bone formation.