PERSONAL DE APOYO
LEWICKI Marianela
congresos y reuniones científicas
Título:
Efecto del cloruro de estroncio en animales ovariectomizados y con periodontitis experimental.
Autor/es:
GOYA JA; LEWICKI M; ESCUDERO ND; MANDALUNIS PM
Lugar:
Mar del Plata, Buenos Aires
Reunión:
Congreso; XL Reunión Anual de la Sociedad Argentina de Investigación Odontológica; 2007
Resumen:
During the past few years, the strontium salts have been described as drugs with antiresorptive and anabolic effects and actually are used in pathological situations where bone resorption activity is increased. The objective of the present study was to perform an histomorphometric evaluation of the bone loss in the experimental periodontitis (PE) in ovariectomizated animals (OVX) and treated with strontium chloride (Sr). For this, 40 female Wistar rats were used and they were divided into four groups: Group Sham, Group OVX, Group Sham+Sr, Grupo OVX+Sr. Strontium chloride was administered in drinking water. Three months and a half post OVX/Sham,  EP was induced in all groups by placing a cotton thread ligature around the neck of the first left lower molar for 96 hs; the contralateral molars served as untreated controls (C). The animals were sacrificed 4 days later. The jaws were resected and histologically processed in order to obtain mesio-distally oriented sections. Bone loss was studied by evaluating interradicular bone volume (BV/TV)(%) and the height of  periodontal ligament (PL) (um) at the level of the furcation.  Results obtained from the contralateral molars (without EP) showed  that BV/TV   of OVX+Sr group was significantly greater in relation to OVX group and no statically significant differences with Sham and  Sham+Sr groups (Sham: 42 ± 3, OVX: 35 ± 3, Sham+Sr 44± 7, OVX+Sr: 43 ± 6). Results of molars with EP showed a minor, but no statically significant,  bone loss in both groups treated with Sr (Sham: 33±4.6, OVX: 29±3.3, Sham+Sr: 37±4.3, OVX+Sr: 38±5.9). No statically significant differences in PL (um) were found between groups.  
The present work demonstrate that Sr inhibits OVX-induced bone loss and further studies are necessary to determine its efficiency to inhibit the bone loss produced by the periodontitis.Key words:  experimental periodontitis, ovariectomy, strontium, bone histomorphometry.    UBACyT O 013